Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
Identifieur interne : 002904 ( Main/Exploration ); précédent : 002903; suivant : 002905Sexually dimorphic postural adjustments during vertical behaviour are altered in a unilateral 6-OHDA rat model of Parkinson's disease
Auteurs : Evelyn F. Field [Canada] ; Gerlinde A. Metz [Canada] ; Sergio M. Pellis [Canada] ; Ian Q. Whishaw [Canada]Source :
- Behavioural brain research [ 0166-4328 ] ; 2006.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Analysis of Variance, Animal, Animal model, Animals, Apomorphine (pharmacology), Behavior, Behavior, Animal (drug effects), Biomechanical Phenomena, Disease Models, Animal, Dopamine Agonists (pharmacology), Female, Functional Laterality, Immunohistochemistry (methods), Kinematics, Male, Movement (drug effects), Movement (physiology), Oxidopamine, Oxidopamine (toxicity), Parkinson Disease (etiology), Parkinson Disease (physiopathology), Parkinson disease, Postural fitting, Posture, Posture (physiology), Psychomotor Performance (physiology), Rat, Rats, Rats, Long-Evans, Rotarod Performance Test (methods), Sex, Sex Characteristics, Sex Factors, Sexual dimorphism, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Tyrosine 3-Monooxygenase.
- chemical , pharmacology : Apomorphine, Dopamine Agonists.
- drug effects : Behavior, Animal, Movement.
- etiology : Parkinson Disease.
- methods : Immunohistochemistry, Rotarod Performance Test.
- physiology : Movement, Posture, Psychomotor Performance.
- physiopathology : Parkinson Disease.
- chemical , toxicity : Oxidopamine.
- Analysis of Variance, Animals, Biomechanical Phenomena, Disease Models, Animal, Female, Functional Laterality, Male, Rats, Rats, Long-Evans, Sex Characteristics, Sex Factors.
Abstract
The study of sex differences in the onset, progression and symptoms of Parkinson's disease, in humans, has led to mixed results. In this study, we used a unilateral 6-hydroxydopamine (6-OHDA) lesion animal model of Parkinson's disease, to address whether there are sex differences in the composition of the movements used during vertical exploration within a confined cylinder. Tyrosine hydroxylase staining and apomorphine induced rotation were used to confirm lesion magnitude. There were no sex differences or lesion effects in the frequency of occurrence of a vertical bout or the average time spent vertical. Both male and female 6-OHDA animals exhibited equal impairments in the use of the forelimbs during vertical exploration. 6-OHDA males, as compared to 6-OHDA females, however, had a significant reduction in the use of their hindlimbs. An analysis of hindlimb step direction revealed that while sham females were more likely to step forward, sham males were more likely to step backwards during a vertical bout. This sex difference was no longer present in the 6-OHDA animals. Finally, 6-OHDA males were significantly more likely to place their dorsal surface in contact with the wall of the cylinder to maintain an upright posture during a vertical bout than animals in any other condition. These results demonstrate that the use of a confined cylinder task is appropriate for the kinematic analysis of sex differences in vertical behaviour and show that there are sex differences in motor behaviour in an animal model of human Parkinson's disease.
Affiliations:
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Field</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscienre, Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s2>Lethbridge, Alta. TIK 3M4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Lethbridge, Alta. TIK 3M4</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Physiology and Biophysics, Hotchkiss Brain Institute, University of Calgary</s1><s2>Calgary, Alta. T2N 4N1</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Metz, Gerlinde A" sort="Metz, Gerlinde A" uniqKey="Metz G" first="Gerlinde A." last="Metz">Gerlinde A. Metz</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscienre, Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s2>Lethbridge, Alta. TIK 3M4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Lethbridge, Alta. TIK 3M4</wicri:noRegion></affiliation></author><author><name sortKey="Pellis, Sergio M" sort="Pellis, Sergio M" uniqKey="Pellis S" first="Sergio M." last="Pellis">Sergio M. Pellis</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscienre, Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s2>Lethbridge, Alta. TIK 3M4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Lethbridge, Alta. TIK 3M4</wicri:noRegion></affiliation></author><author><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neuroscienre, Canadian Centre for Behavioural Neuroscience, University of Lethbridge</s1><s2>Lethbridge, Alta. TIK 3M4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Lethbridge, Alta. TIK 3M4</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Behavioural brain research</title><title level="j" type="abbreviated">Behav. brain res.</title><idno type="ISSN">0166-4328</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Behavioural brain research</title><title level="j" type="abbreviated">Behav. brain res.</title><idno type="ISSN">0166-4328</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Animal</term><term>Animal model</term><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Behavior</term><term>Behavior, Animal (drug effects)</term><term>Biomechanical Phenomena</term><term>Disease Models, Animal</term><term>Dopamine Agonists (pharmacology)</term><term>Female</term><term>Functional Laterality</term><term>Immunohistochemistry (methods)</term><term>Kinematics</term><term>Male</term><term>Movement (drug effects)</term><term>Movement (physiology)</term><term>Oxidopamine</term><term>Oxidopamine (toxicity)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Postural fitting</term><term>Posture</term><term>Posture (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Rat</term><term>Rats</term><term>Rats, Long-Evans</term><term>Rotarod Performance Test (methods)</term><term>Sex</term><term>Sex Characteristics</term><term>Sex Factors</term><term>Sexual dimorphism</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Movement</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunohistochemistry</term><term>Rotarod Performance Test</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Posture</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Oxidopamine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Animals</term><term>Biomechanical Phenomena</term><term>Disease Models, Animal</term><term>Female</term><term>Functional Laterality</term><term>Male</term><term>Rats</term><term>Rats, Long-Evans</term><term>Sex Characteristics</term><term>Sex Factors</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dimorphisme sexuel</term><term>Ajustement postural</term><term>Comportement</term><term>Oxidopamine</term><term>Modèle animal</term><term>Rat</term><term>Parkinson maladie</term><term>Sexe</term><term>Cinématique</term><term>Posture</term><term>Animal</term><term>Mâle</term><term>Femelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The study of sex differences in the onset, progression and symptoms of Parkinson's disease, in humans, has led to mixed results. In this study, we used a unilateral 6-hydroxydopamine (6-OHDA) lesion animal model of Parkinson's disease, to address whether there are sex differences in the composition of the movements used during vertical exploration within a confined cylinder. Tyrosine hydroxylase staining and apomorphine induced rotation were used to confirm lesion magnitude. There were no sex differences or lesion effects in the frequency of occurrence of a vertical bout or the average time spent vertical. Both male and female 6-OHDA animals exhibited equal impairments in the use of the forelimbs during vertical exploration. 6-OHDA males, as compared to 6-OHDA females, however, had a significant reduction in the use of their hindlimbs. An analysis of hindlimb step direction revealed that while sham females were more likely to step forward, sham males were more likely to step backwards during a vertical bout. This sex difference was no longer present in the 6-OHDA animals. Finally, 6-OHDA males were significantly more likely to place their dorsal surface in contact with the wall of the cylinder to maintain an upright posture during a vertical bout than animals in any other condition. These results demonstrate that the use of a confined cylinder task is appropriate for the kinematic analysis of sex differences in vertical behaviour and show that there are sex differences in motor behaviour in an animal model of human Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Field, Evelyn F" sort="Field, Evelyn F" uniqKey="Field E" first="Evelyn F." last="Field">Evelyn F. Field</name></noRegion><name sortKey="Field, Evelyn F" sort="Field, Evelyn F" uniqKey="Field E" first="Evelyn F." last="Field">Evelyn F. Field</name><name sortKey="Metz, Gerlinde A" sort="Metz, Gerlinde A" uniqKey="Metz G" first="Gerlinde A." last="Metz">Gerlinde A. Metz</name><name sortKey="Pellis, Sergio M" sort="Pellis, Sergio M" uniqKey="Pellis S" first="Sergio M." last="Pellis">Sergio M. Pellis</name><name sortKey="Whishaw, Ian Q" sort="Whishaw, Ian Q" uniqKey="Whishaw I" first="Ian Q." last="Whishaw">Ian Q. Whishaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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